Muramyl peptidesleep Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide that plays a crucial role in biological processes, particularly as a component of bacterial cell walls and a ligand for NOD2 receptors. For researchers and institutions seeking to acquire this compound, understanding its availability, typical purities, and various applications is essential when looking for muramyl peptide for sale. While some listings may be restricted, the scientific community can often find MDP from specialized chemical suppliers, with common purities exceeding 98% and available in research-grade quantitiesMuramyl Dipeptide (6366) by Tocris, Part of Bio-Techne.
Muramyl dipeptide, often abbreviated as MDP, is the minimal bioactive unit of peptidoglycans found in the cell walls of nearly all bacteria. Chemically, it consists of N-acetyl muramic acid attached to a short chain of amino acids, typically L-Ala-D-isoGln.Muramyl Dipeptide (CAS 53678-77-6) This structure makes it a significant molecule in immunology and microbiologyAc-muramyl-Ala-D-Glu-NH₂ - Bachem Products. MDP acts as a potent activator of the NOD2 receptor, a key component of the innate immune system.Dipeptide Beyond its immunological functions, research indicates that MDP can also induce bone formation by activating Runx2, a transcription factor crucial for osteoblast differentiation.
When searching for muramyl peptide for sale, users will encounter various suppliers catering to research and development needs.Muramyl dipeptide (MDP) is a ligand for nucleotide-binding oligomerization domain-containing 2 (NOD2) and a breakdown product of bacterial cell wall ... Products are typically offered with specified purities, such as >98% or ≥95% (mixture of anomers), and in standard research quantities like 1 mg or 5 mg, with pricing often reflecting these specificationsMifaMurtide | Buy from Supplier AdooQ®. For instance, a 5 mg quantity might range from approximately $214.00 upwards, with bulk or custom quotes available for larger orders.
It's important to note that some suppliers may have territorial restrictions or class the product as a controlled substance, limiting its sale in certain regions. However, established chemical suppliers like Merck, Cayman Chemical, and others frequently list Muramyl Dipeptide (CAS 53678-77-6) in their catalogs, often accompanied by detailed product information, including molecular weight (e.g., 492.5 Da) and safety data sheets (MSDS)Muramyl peptides take part in the process of hematopoiesis, stimulating production of colony-stimulating factors, which is the basis for their use in the .... Some vendors also offer specific formulations or analogues, such as Mifamurtide, a liposomal formulation of an MDP analogue, or Licopid (Glucosaminyl muramyl dipeptide), known for its immune-stimulating properties.
The scientific interest in muramyl dipeptide stems from its diverse biological activities. Its role as a NOD2 ligand makes it a valuable tool for studying innate immunity, inflammation, and host-pathogen interactionsMuramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln.. Research involving MDP has explored its potential in:
* Immunomodulation: MDP is recognized for its ability to stimulate the immune system.Muramyl dipeptide (MDP) directly augments osteoblast differentiation and bone-forming gene expression by Runx2 activation. Despite no direct effect, ... It can induce polarization of immune cells and has been investigated for its effects on hematopoiesis, including the stimulation of colony-stimulating factors.
* Bone Formation: Studies have shown that MDP can directly enhance osteoblast differentiation and bone formation through the activation of Runx2. This has led to interest in its potential therapeutic applications in bone-related conditions.
* Adjuvant Activity: Synthetic analogues of MDP have demonstrated excellent adjuvant activity, enhancing the immune response to co-administered antigens. This makes them valuable components in vaccine development.
* Inflammatory Conditions: As an inducer of inflammatory responses via NOD2 activation, MDP is studied in the context of various inflammatory diseases.
While the primary use of commercially available muramyl dipeptide is for laboratory research, its biological activities have also led to the development of related therapeutic compounds. For example, Mifamurtide and Licopid are examples of drugs derived from or related to muramyl dipeptide, targeting immune modulation and anti-inflammatory effects.
When procuring muramyl dipeptide, researchers should ensure the supplier provides comprehensive documentation, including purity analysis and safety information, to support their experimental needs. The availability of this compound facilitates ongoing research into its multifaceted biological roles and potential therapeutic applications.
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