DNSP-11 dosage The DNSP-11 peptide, also known as Dopamine Neuron Stimulating Peptide-11, is an 11-amino acid synthetic peptide derived from the pro-domain of human Glial Cell Line-Derived Neurotrophic Factor (GDNF)作者：YA Sidorova·2020·被引用次数：24—A predicted endopeptidase cleavage product from the GDNF proregion called DNSP-11, a peptide thatincludes 11 consecutive amino acid residuesfrom the proregion .... Research indicates that DNSP-11 exhibits significant neurotrophic and neuroprotective properties, particularly towards dopamine neuronsa The predicted enzymatic processing of DNSP-11 in .... This peptide has demonstrated the ability to support the survival of these critical neurons and offers protection against cell death induced by various damaging agents, making it a subject of considerable interest in neurological research.
DNSP-11 originates from the pro-GDNF domain, a region of the GDNF protein that is processed to yield the mature GDNF. Unlike GDNF itself, DNSP-11 is a specific cleavage product, an 11-mer peptide, that retains important bioactivity. Its synthetic nature allows for controlled production and purification, with high purity (≥98% HPLC) being a standard for research-grade material. This precise composition is key to its predictable effects on neural cells.The neuroprotective actions of dopamine neuron ...
A primary focus of research into DNSP-11 is its potent neuroprotective activity. Studies have shown that DNSP-11 can shield dopaminergic neuroblastoma cells from apoptotic cell death, a critical process implicated in neurodegenerative diseases. This protection extends to cell death induced by agents like staurosporine and 6-hydroxydopamine (6-OHDA), a neurotoxin commonly used in animal models to mimic Parkinson's disease.Molecular and Cellular Characterization of Dopamine Neuron ... Furthermore, DNSP-11 has been observed to activate neuroprotective signaling pathways, such as the ERK signaling cascade, which plays a vital role in cell survival and function. Beyond protection, DNSP-11 also promotes the survival of fetal mesencephalic neurons, suggesting a broader role in supporting neuronal health and development.
The ability to effectively deliver therapeutic agents to the central nervous system (CNS) is a significant challenge in neuroscience. DNSP-11 has shown promise with intranasal delivery methods. Studies indicate that DNSP-11 can be administered intranasally and maintain its neuroactive properties, reaching the CNS and exerting its beneficial effects. This non-invasive delivery route is particularly attractive for potential therapeutic applications, offering a more accessible method compared to direct injection into the brain作者：JL Fuqua·2014·被引用次数：17—...11-amino-acidpeptidenamed dopamine neuron stimulatingpeptide-11(DNSP-11). A single treatment ofDNSP-11was delivered to the substantia nigra in the rat .... The research exploring repeated intranasal delivery of DNSP-11 in animal models of Parkinson's disease further supports its potential as an easily administrable therapeutic agent.
DNSP-11 is primarily utilized as a specialized research peptide for advanced scientific exploration in neurobiologyTargeting the hypothalamic a11 nucleus to treat parkinsonian-like .... Its established effects on dopamine neurons make it a valuable tool for investigating the mechanisms underlying neuroprotection and neurotrophic support. Researchers are exploring its potential in models of Parkinson's disease, where the degeneration of dopamine neurons is a hallmarkThe present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (GDNF)peptides(or “Dopamine Neuron .... While still in the research phase, the consistent demonstration of positive effects in cellular and animal models positions DNSP-11 as a peptide of significant interest for future therapeutic development. Further studies are ongoing to fully elucidate its mechanisms of action and to assess its efficacy and safety in various neurological contexts.
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