GLP-1antibody The search query "glucagon like peptide 1 antibody" indicates a strong interest in understanding and acquiring antibodies that target Glucagon-like peptide 1 (GLP-1). This includes information on their applications, types, and where to find themAnti-GLP-1 antibody [EPR4042-1] (ab108443). The dominant search intent is informational and commercial, with users seeking to learn about GLP-1 antibodies for research purposes and potentially to purchase them.作者：EK Biggs·2018·被引用次数：33—Glp1R0017 is a monoclonal antagonisticantibodyto the GLP1R that binds to GLP1R on pancreatic beta cells and blocks the actions ofGLP-1in vivo.
Glucagon-like peptide 1 (GLP-1) antibodies are crucial tools in biological research, enabling scientists to detect, quantify, and study the GLP-1 hormone and its related pathways. These antibodies are indispensable for a range of scientific applications, including Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), and Enzyme-Linked Immunosorbent Assay (ELISA).Invitrogen Anti-GLP-1 Monoclonal (10), Catalog # ABS 033-10-02. Tested in ELISA (ELISA) applications. This antibody reacts with Human samples. Understanding the nuances of these antibodies, from their specificity to their various applications, is key for researchers in endocrinology, metabolism, and diabetes research.
GLP-1 itself is a peptide hormone belonging to the glucagon family, primarily produced by L cells in the intestinal mucosa.Antibodies that detect GLP-1can be used in several scientific applications, including ELISA, Immunohistochemistry, Western Blot and Immunocytochemistry. It plays a significant role in glucose homeostasis, acting as a potent stimulator of glucose-dependent insulin release and suppressing glucagon levels. Its functions also extend to gastric motility. Consequently, antibodies that specifically target GLP-1 are vital for investigating these physiological processes and exploring potential therapeutic targets.
The landscape of GLP-1 antibodies is diverse, offering researchers various options based on their specific experimental needs. These antibodies can be broadly categorized by their origin and specificity.
* Monoclonal vsGLP-1 Antibody. Polyclonal Antibodies: Researchers can choose between monoclonal antibodies, which are derived from a single clone of B cells and recognize a specific epitope on the GLP-1 molecule, or polyclonal antibodies, which are a mixture of antibodies recognizing multiple epitopes. Monoclonal antibodies generally offer higher specificity and batch-to-batch consistency, while polyclonal antibodies can sometimes provide broader coverage and higher signal in certain assays.
* Applications in Research: The utility of GLP-1 antibodies spans across several common laboratory techniques:
* Western Blot (WB): Used to detect the presence and size of GLP-1 protein in cell or tissue lysatesAntibody T-4363.
* Immunohistochemistry (IHC): Enables the visualization of GLP-1 protein localization within tissue sections, providing insights into where the hormone is produced and expressed.
* Immunocytochemistry (ICC) / Immunofluorescence (IF): Similar to IHC but used for cells, allowing for the study of GLP-1 expression at the cellular level.GLP-1 Agonists
* ELISA: A highly sensitive method for quantifying GLP-1 levels in biological fluids like plasma or serum, crucial for metabolic studies.
Some antibodies are designed to detect specific forms or fragments of GLP-1, such as GLP-1 (7-37) or GLP-1 (1-37), which is important for studies focusing on the active or precursor forms of the hormone.GLP-1 Antibody | Rabbit Monoclonal | RQ4965 NSJ ... Additionally, antibodies targeting the GLP-1 receptor (GLP-1R) are also available, enabling research into how GLP-1 exerts its effects on target cells.作者：EK Biggs·2018·被引用次数：33—Glp1R0017 is a monoclonal antagonisticantibodyto the GLP1R that binds to GLP1R on pancreatic beta cells and blocks the actions ofGLP-1in vivo.
When acquiring GLP-1 antibodies, researchers often utilize antibody search and comparison tools provided by various scientific suppliers.GLP-1抗体[11E2] (ab23468)| Abcam中文官网 These platforms allow for the comparison of specifications, prices, citations, and reviews from different manufacturers.GLP-1 Antibody Reputable suppliers, such as Invitrogen, Abcam, Santa Cruz Biotechnology, and R&D Systems, offer a wide range of GLP-1 antibodies, including monoclonal and polyclonal options validated for specific applications and species.Anti-Glucagon-like Peptide 1 Receptor antibodies areavailable from several suppliers. In humans, this protein is encoded by the gene GLP1R.
When selecting a GLP-1 antibody, several factors are critical:
* Validated Applications: Ensure the antibody has been tested and validated for the specific assay you intend to perform (e.g., WB, IHC, ELISA).
* Species Reactivity: Confirm that the antibody reacts with the species of interest (eAntibody T-4363.Glucagon-Like Peptide-1 (GLP-1), (7-37), neat antiserum. Clone: polyclonal; Format: neat serum, lyophilized; Applications: ELISA (IHC, others) ....g., human, mouse, rat).GLP-1 Antibody | Rabbit Monoclonal | RQ4965 NSJ ...
* Specificity: Check for information regarding cross-reactivity with other proteins, particularly those structurally similar like glucagonGLP-1 is an incretin hormone with various effects. Guinea pig polyclonal purified antibody. Cat. No.: 471 005. Amount: 50 μg. Price: 5.00.. Antibodies that bind to specific epitopes or forms of GLP-1 may be preferred for certain studies.
* Quality and Consistency: Look for antibodies from established manufacturers with good track records for quality control and lot-to-lot consistency, especially for quantitative assays.
* Supporting Data: Review provided data such as reference citations, performance graphs, and protocol recommendations.
The availability of GLP-1 antibodies from numerous suppliers reflects their significance in advancing research related to incretin hormone signaling and metabolism. These antibodies are fundamental tools for understanding the role of GLP-1 in physiological processes and in the development of therapeutic strategies for conditions like type 2 diabetes, where GLP-1 agonists are increasingly utilized.
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