Mevgwyrspfsrvvhlyrngk The MOG (35-55) peptide is a crucial synthetic fragment derived from Myelin Oligodendrocyte Glycoprotein (MOG), a key component of the central nervous system's myelin sheath. This peptide is widely recognized for its ability to induce experimental autoimmune encephalomyelitis (EAE) in animal models, a condition that closely mimics human demyelinating diseases such as multiple sclerosis (MS). By studying the effects of the MOG (35-55) peptide, researchers gain invaluable insights into the autoimmune processes that lead to the destruction of myelin, offering pathways for developing diagnostic tools and therapeutic strategies.
Experimental autoimmune encephalomyelitis (EAE) serves as the primary animal model for studying MS and other inflammatory demyelinating disorders.MOG (35-55) TFA (Myelin Oligodendrocyte Glycoprotein ... The MOG (35-55) peptide is the immunodominant epitope within the MOG protein responsible for triggering this autoimmune response. When administered to susceptible animal species, such as mice and rats, this peptide elicits a robust immune reaction. Specifically, it stimulates T-cell responses that target the myelin sheath, leading to inflammation, plaque-like demyelination, and neurological deficits that mirror the symptoms observed in MS patients作者：M Rodi·2024·被引用次数：2—This work demonstrate that OM-MOG35–55 could form the basis for the development of personalized therapeutic vaccines or immunomodulatory treatments for MS.. This controlled induction of EAE using the MOG (35-55) fragment allows scientists to investigate the intricate mechanisms of autoimmune attack, the role of specific immune cells and cytokines, and the development of disease pathology.
The amino acid sequence of the MOG (35-55) peptide, often represented as MEVGWYRPPFSRVVHLYRNGK, is critical for its immunogenic properties. Variations exist in the peptide sequence between different species, such as human and murine MOG (35-55), which can influence the immune response and the severity of EAE.MOG [35-55] Peptide (Rat) Research has also explored modifications to the peptide, including citrullinated forms, to understand how subtle changes can alter immunogenicity and antigen recognition.Thispeptideinduces severe chronic experimental autoimmune encephalomyelitis in transgenic mice. The precise sequence and any modifications are vital considerations for researchers aiming to accurately replicate disease models and understand specific immune interactions.
The MOG (35-55) peptide is not only instrumental in disease modeling but also holds potential for therapeutic developmentMOG (35-55) is able toinduce autoantibody production and relapsing-remitting neurological diseasecausing extensive plaque-like demyelination.. Studies investigating the intravenous administration of MOG (35-55) peptide have shown its capacity to suppress the inflammatory pathways involved in EAE, suggesting possible immunomodulatory treatments for autoimmune demyelinating diseasesMOG (35-55) (human). £85.00 1mg. SKU: NR-010 Categories: Antibodies, MyelinPeptides.... Furthermore, the peptide is used in T-cell assays to identify and characterize antigen-specific T-cell responses associated with MS.Myelin Oligodendrocyte Glycoprotein Peptide (35-55), Rat, ... This application aids in understanding disease pathogenesis and in developing personalized therapeutic vaccines or immunomodulatory treatments tailored to individual immune profiles.
Researchers typically source MOG (35-55) peptide from specialized biochemical suppliersProteins andPeptides MOG [35-55]Peptide(Rat) · 350275 · Brand · Description · Application · Reactivity · Photos · 歡迎填寫資料獲得亞旭第一手資訊. Δ.. The purity of the peptide is paramount for reliable experimental outcomes, as contaminants can lead to confounding results. Different forms of the peptide are available, including trifluoroacetate (TFA) salts, with varying quantities offered to suit research needs. It is important to note that these peptides are chemical reagents intended for research use only and are not for human consumption.
The MOG (35-55) peptide remains an indispensable tool in neuroscience and immunology research, particularly in the study of demyelinating diseases. Its ability to reliably induce EAE provides a critical window into the complex autoimmune mechanisms underlying conditions like multiple sclerosisMOG (35-55) peptide, mouse. Continued research utilizing this peptide not only deepens our understanding of disease pathogenesis but also paves the way for innovative therapeutic interventions aimed at halting or reversing myelin damage and restoring neurological function.
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