peptide-glp-1-agonist Peptide gold nanoparticles represent a sophisticated class of nanomaterials, leveraging the unique physicochemical properties of gold nanoparticles (AuNPs) and the versatile functionality of peptides.作者：X Liu·2016·被引用次数：98—Peptide-functionalized gold nanoparticles (AuNPs) are extensively utilized in colorimetric assays for rapid and sensitive detection of various biomedical ... This integration yields hybrid structures with enhanced stability, targeted delivery capabilities, and novel optical or catalytic properties, paving the way for significant advancements in fields such as diagnostics, therapeutics, and biomimetic technologies. The precise control offered by peptides in guiding the synthesis, assembly, and functionalization of gold nanoparticles is a key driver of their growing importanceGold Nanoparticle-Conjugated Peptide Synthesis.
The creation of peptide gold nanoparticles involves several key approaches, primarily focusing on using peptides to direct the formation and surface modification of AuNPs. One prominent method is peptide-mediated synthesis, where peptides act as reducing and capping agents to control the growth and size of gold nanoparticles.作者：Y Li·2014·被引用次数：144—Biomimetic nanotechnologies that use peptidesto guide the growth and assembly of nanostructures offer new avenues for the creation of functional ... This biomimetic approach offers a "green" and simple route to producing functional nanoparticles. For instance, specific amino acids or peptides can influence the chirality of the resulting gold nanoparticles, leading to optically active structures.
Beyond direct synthesis, peptides are frequently employed to functionalize pre-formed gold nanoparticles. This peptide-functionalization strategy is crucial for imparting specific biological recognition or therapeutic functions. Peptides can be attached to the surface of AuNPs, creating hybrid nanoarchitectonics with tailored properties.2018年5月4日—The researchers observed that the chirality ofpeptidescan be directly transferred togold nanoparticles. The resulting chiral nanoparticles ... This includes developing peptide-coated AuNPs that exhibit enzyme-like structures or properties, or those designed for targeted delivery, such as the pHLIP peptide which can target nanogold particles to tumors.
The combination of peptides and gold nanoparticles results in materials with a unique set of advantageous properties. Gold nanoparticles themselves possess exceptional physicochemical characteristics, including high extinction coefficients and excellent biocompatibility, making them highly promising for various biomedical applications. When functionalized with peptides, these nanoparticles gain enhanced stability, preventing aggregation and improving their performance in biological environments.
Furthermore, peptides can confer specificity to gold nanoparticles.One Step Preparation of Peptide-Coated Gold ... For example, peptide-drug conjugates utilizing gold nanoparticles as carriers can improve the stability and cellular uptake of therapeutic peptides, holding potential for enhanced drug efficacyGold Nanoparticle-Conjugated Peptide Synthesis. The ability of peptides to direct the assembly of nanostructures also allows for the creation of ordered peptide-gold nanoparticle hybrids with specific optical properties, such as those utilized in NanoPACK technology for enhanced sensitivity in diagnostic assays. The chirality of peptides can also be transferred to gold nanoparticles, yielding chiral gold nanoparticles with unique optical activity.
The versatility of peptide gold nanoparticles has led to their exploration in a wide array of biomedical applications. Their inherent properties make them suitable for diagnostics, imaging, and therapy.
* Therapeutics: Peptide-functionalized gold nanoparticles show promise as drug delivery vehicles. They can stabilize peptide-drug conjugates, improving their targeting efficiency and potentially overcoming limitations like short half-lives. For instance, they can be designed to target cancer cells or other specific tissues, delivering therapeutic payloads with greater precision.作者：J Zong·2017·被引用次数：201—In this review, we will give an overview of thecurrent methods used for preparing peptide functionalized GNPs, and we will discuss their key properties.
* Diagnostics and Imaging: The unique optical properties of gold nanoparticles, such as surface plasmon resonance, coupled with peptide-based targeting, make them excellent candidates for diagnostic assays and imaging agents. Peptide-functionalized AuNPs are extensively utilized in colorimetric assays for the rapid and sensitive detection of various biomarkers, including cardiac troponin I作者：Y Pérez·2011·被引用次数：21—Gold nanoparticles were prepared using peptide–biphenyl hybrids (PBHs) as capping agents. AuNPs were characterized by different techniques including UV–Vis, .... They can also be used for in vivo imaging, particularly when functionalized with peptides that target specific cellular or tissue environments.
* Biomimetic Technologies: Peptides serve as valuable tools for controlled nanomaterial creation, guiding the synthesis and organization of gold nanostructures. This biomimetic approach opens new avenues for creating functional materials that mimic biological processes or structures.
While the field of peptide gold nanoparticles is rapidly advancing, several challenges remain. Optimizing synthesis methods for reproducibility and scalability is crucial for widespread adoption. Further research into understanding the complex interactions between peptides and gold nanoparticles at the molecular level will facilitate the design of even more sophisticated and effective nanomaterials. Ensuring long-term stability and biocompatibility in complex biological systems, as well as addressing potential toxicity concerns, are also critical areas for ongoing investigation.Synthesis and Organization of Gold-Peptide Nanoparticles for ... Despite these challenges, the synergistic combination of peptides and gold nanoparticles offers a powerful platform for developing next-generation diagnostic and therapeutic tools.作者：Y Jia·2019·被引用次数：33—Peptide-coated AuNPswith precise different sizes can be prepared by this method through pH control of reducing reagent tyrosine in range of 10.0~12.7.
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