Bombesintumor marker Bombesin-like peptides are a diverse group of neuropeptides that play significant roles in physiological processes, including appetite regulation, stress response, and cell growth作者：JH Walsh·1979·被引用次数：284—Abstract.Acid extracts of rat gut and braincontain substances that cross-react in a radioimmunoassay for the amphibian skin tetradecapeptide bombesin.. Originally discovered in amphibian skin, these peptides and their mammalian counterparts, such as gastrin-releasing peptide (GRP) and neuromedin B (NMB), are now recognized for their widespread presence and multifaceted functions in vertebrates.Bombesin-like peptides are defined asa group of peptides that share sequence homology and biological effectswith the amphibian peptide bombesin, ... The study of bombesin-like peptides is crucial for understanding their involvement in both normal bodily functions and various pathological conditions, particularly in cancer.
The journey of bombesin-like peptides began with the isolation of bombesin itself from the skin of the frog *Bombina bombina*. Subsequent research revealed that mammals possess related peptides that share sequence homology and biological effects with amphibian bombesinBombesin-like Peptides | Modulators of Inflammation in .... The primary mammalian equivalents are gastrin-releasing peptide (GRP) and neuromedin B (NMB).作者：ER Spindel·1996·被引用次数：16—Bombesin-like Peptides: From Frog Skin to Human Lung. York E. Miller, Am J Respir Cell Mol Biol, 1990. Bombesin-Like Peptides in Health and Disease. These peptides, along with others, form distinct subfamilies, including the GRP, NMB, and BRP families, highlighting their evolutionary diversity.Bombesin-like peptides can function as autocrine growth ...
Bombesin-like peptides are implicated in a wide array of physiological functions.Characterization and distribution of bombesin-like peptides ... One of their well-documented roles is the regulation of food intake; they can inhibit appetite when administered peripherally or centrally, acting on satiety mechanisms. Beyond appetite control, these peptides are involved in mediating stress responses, influencing normal lung development, and modulating inflammation. Their actions are often mediated through specific receptors, such as the BB1 and BB2 receptors, which are part of the mammalian bombesin receptor system. This system is crucial for regulating energy homeostasis, making it a potential target for pharmacological interventions related to metabolic disorders.Bombesin-like peptides inhibit food intakewhen injected either peripherally or centrally by acting on satiety.
A significant area of research concerning bombesin-like peptides is their role in cell growth and their association with cancer. They have been shown to promote the growth of various cell lines, including those found in carcinomas.Bombesin-like peptidescomprise a large family of peptides which were initially isolated from amphibian skin, where they stimulate smooth muscle contraction ... In several forms of cancer, such as lung, prostate, breast, and colon cancers, bombesin-like peptides are over-expressed.作者：F Cuttitta·1985·被引用次数：1734—We demonstrate that a monoclonal antibody tobombesinbinds to the C-terminal region of BLPs, blocks the binding of the hormone to cellular receptors and ... This overexpression, often acting through an autocrine or paracrine mechanism where cells produce substances that act on themselves or nearby cells, suggests a critical role in tumor development and progression.作者：H Ohki-Hamazaki·2005·被引用次数：227—Bombesinand two majorbombesin-like peptidein mammals, gastrin-releasing peptide (GRP) and neuromedin B (NMB), have been shown to elicit various ... The gastrin-releasing peptide receptor (GRPr), for instance, is highly overexpressed on prostate cancer cells, making bombesin analogues potential tools for targeted therapies and diagnostic imaging.Bombesin-like peptides – Knowledge and References
The diverse functions and implications of bombesin-like peptides have spurred considerable research. Studies have focused on their biochemical characterization, distribution within the body (e.g.Bombesin and bombesin-like peptides have a wide range of functions.They have been shown to promote cell growth, including that of carcinoma cell lines, they ..., higher concentrations found in the antrum compared to the brain), and their mechanisms of action, including their ability to activate protein kinase C作者：ID Majumdar·2011·被引用次数：62—Mammalian bombesin receptors participate in the regulation of energy homeostasisand may represent an attractive target for pharmacological treatment of .... The development of novel bombesin-like peptides and analogues, such as those designed for GRP-receptor targeting, holds promise for therapeutic applications. These include potential treatments for obesity, stress-related disorders, and various cancers, leveraging their ability to modulate specific cellular pathways and receptors.
In conclusion, bombesin-like peptides represent a fascinating and vital class of signaling molecules. From their initial discovery in amphibians to their complex roles in mammalian physiology and pathology, ongoing research continues to uncover their significance in areas ranging from metabolism and stress to cancer biology, offering exciting prospects for future medical advancements.
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